FA Cup wins for both sides last weekend cannot mask poor league form and this match takes on increased importance after their lack of points in recent weeks.
Although Watford are tenth in the table, Marco Silva’s side are only five points clear of the relegation zone and cannot afford to slip up this weekend.
Southampton also desperately need a win after a run of nine games without a victory in the league which has left them only above the bottom three on goal difference.
The Saints won at Fulham in the cup but their league form is pretty dire and away from home have only managed to win at Crystal Palace back in September.
Silva’s side easily defeated Bristol City last weekend but the focus is back on turning around their league form after a run of six defeats in their last seven games.
Watford made an excellent start to the season, which included a win at Southampton but the Hornets have to address their current form otherwise the team will quickly drop down towards the bottom three.
The last home defeat, a 2-1 loss to bottom side Swansea, was a low point for the side but the Hornets should be able to put this behind them against a side lacking goals. Southampton have only scored 21 goals in 22 league matches and their lack of cutting edge could threaten their top-flight status this season.
Opposition player most feared
This Southampton team certainly does not offer too many threats especially with goalscorer Charlie Austin out injured. Sofiane Boufal is an enigma and the Moroccan is a frustrating player. But the midfielder, who was linked with a move to Watford before joining the Saints, is capable of occasional brilliance as he showed in his superb individual goal against West Brom earlier this season.
Predicted Starting XI
Troy Deeney is likely to keep his place up front after the Watford captain returned from suspension with a goal in the 3-0 win over Bristol City. He should be joined in the attack by Richarlison after the Brazilian was on the bench last weekend.
Possible lineup: Heurelho Gomes; Daryl Janmaat, Christian Kabasele, Molly Wague, Marvin Zeegelaar; Tom Cleverley, Ben Watson, Abdoulaye Doucoure, Andre Carrillo; Troy Deeney, Richarlison.
Watford must be favourites for this game at Vicarage Road and the hosts look worth backing to claim a much-needed win.
The Hornets won 2-0 at Southampton earlier this season and Silva’s side are fancied to complete the double over them, so I'll go for a similar scoreline.
We have a field day as the Saints are still acclimatising to life without Virgil van Dijk. I'll allow them a late Charlie Austin consolation goal, though. Watford to win 3-1.